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Entospletinib

CAS No. 1229208-44-9

Entospletinib ( Entospletinib; GS9973; GS 9973 )

Catalog No. M17895 CAS No. 1229208-44-9

Entospletinib （IC50= 7.7 nM）is a specific Syk inhibitor, which is orally bioavailable.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 41 In Stock
5MG 67 In Stock
10MG 88 In Stock
25MG 160 In Stock
50MG 245 In Stock
100MG 394 In Stock
200MG 584 In Stock
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Biological Information

  • Product Name
    Entospletinib
  • Note
    Research use only, not for human use.
  • Brief Description
    Entospletinib （IC50= 7.7 nM）is a specific Syk inhibitor, which is orally bioavailable.
  • Description
    Entospletinib, also known as GS-9973, is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications. In Phase II clinical trials, Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity.
  • Synonyms
    Entospletinib; GS9973; GS 9973
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Syk
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1229208-44-9
  • Formula Weight
    411.47
  • Molecular Formula
    C23H21N7O
  • Purity
    98%
  • Solubility
    DMSO : ≥ 43 mg/mL; 104.51 mM
  • SMILES
    C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)c2ccc3cn[nH]c3c2)cc1
  • Chemical Name
    6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Currie KS, et al. Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase. J Med Chem. 2014 May 8;57(9):3856-73.
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