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Entospletinib
CAS No. 1229208-44-9
Entospletinib ( Entospletinib; GS9973; GS 9973 )
Catalog No. M17895 CAS No. 1229208-44-9
Entospletinib （IC50= 7.7 nM）is a specific Syk inhibitor, which is orally bioavailable.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 160 | In Stock |
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| 50MG | 245 | In Stock |
|
| 100MG | 394 | In Stock |
|
| 200MG | 584 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEntospletinib
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NoteResearch use only, not for human use.
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Brief DescriptionEntospletinib （IC50= 7.7 nM）is a specific Syk inhibitor, which is orally bioavailable.
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DescriptionEntospletinib, also known as GS-9973, is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications. In Phase II clinical trials, Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity.
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SynonymsEntospletinib; GS9973; GS 9973
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorSyk
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1229208-44-9
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Formula Weight411.47
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Molecular FormulaC23H21N7O
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Purity98%
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SolubilityDMSO : ≥ 43 mg/mL; 104.51 mM
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SMILESC1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)c2ccc3cn[nH]c3c2)cc1
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Chemical Name6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Currie KS, et al. Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase. J Med Chem. 2014 May 8;57(9):3856-73.
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