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Enpp-1-IN-14

CAS No. 2687222-59-7

Enpp-1-IN-14( —— )

Catalog No. M28549 CAS No. 2687222-59-7

ENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Enpp-1-IN-14
  • Note
    Research use only, not for human use.
  • Brief Description
    ENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.
  • Description
    ENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.(In Vivo):ENPP1-IN-2 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth in Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells).
  • In Vitro
    ——
  • In Vivo
    Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth. Animal Model:Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)Dosage:50 mg/kg Administration:IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)Result:Significantly inhibited tumor growth.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    KSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2687222-59-7
  • Formula Weight
    403.88
  • Molecular Formula
    C15H22ClN5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 9.62 mg/mL (23.82 mM)
  • SMILES
    Cl.O=S(=O)(N)N1CCN(C=2N=CN=C3C=C(OC)C(OC)=CC32)CCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Woessner R, et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 2009 Nov;29(11):4373-80.
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