Encorafenib

CAS No. 1269440-17-6

Encorafenib ( LGX818; LGX-818; LGX 818; Encorafenib )

Catalog No. M17919 CAS No. 1269440-17-6

LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 77 In Stock
10MG 112 In Stock
25MG 177 In Stock
50MG 337 In Stock
100MG Get Quote In Stock
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500MG Get Quote In Stock
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Biological Information

  • Product Name
    Encorafenib
  • Note
    Research use only, not for human use.
  • Brief Description
    LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
  • Description
    Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells.
  • Synonyms
    LGX818; LGX-818; LGX 818; Encorafenib
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    B-Raf (V600E)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1269440-17-6
  • Formula Weight
    540.01
  • Molecular Formula
    C22H27ClFN7O4S
  • Purity
    98%
  • Solubility
    DMSO : 50 mg/mL 92.59 mM;
  • SMILES
    C[C@@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=CC(=CC(=C3F)NS(=O)(=O)C)Cl)C(C)C)NC(=O)OC
  • Chemical Name
    (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Darrin D Stuart, et al. Cancer Res, 2012, 72(8 Supplement): 3790.
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