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Emlenoflast
CAS No. 1995067-59-8
Emlenoflast( MCC7840 )
Catalog No. M23899 CAS No. 1995067-59-8
Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 284 | In Stock |
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| 10MG | 392 | In Stock |
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| 25MG | 709 | In Stock |
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| 50MG | 1102 | In Stock |
|
| 100MG | 1653 | In Stock |
|
| 200MG | 2480 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEmlenoflast
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NoteResearch use only, not for human use.
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Brief DescriptionEmlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
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DescriptionEmlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
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In VitroEmlenoflast, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM.
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In VivoEmlenoflast (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng?h/mL) and CL (0.621 mL/min/kg) in mice.Emlenoflast (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice. Animal Model:Male C57BL/6 mice (7-9 weeks)Dosage:4 mg/kg for i.v. and 20 mg/kg for p.o. (Pharmacokinetic Analysis)Administration:A single intravenousbolus or oral gavage Result:I.v.: t1/2=3.39 h; AUC0-last=107097 ng?h/mL; CL=0.621 mL/min/kg.P.o.: F=67.2%; Cmax=60467 ng/mL; t1/2=5.02 h.
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SynonymsMCC7840
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PathwayNF-κB
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TargetNOD
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RecptorNLRP3
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Research Area——
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Indication——
Chemical Information
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CAS Number1995067-59-8
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Formula Weight388.48
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Molecular FormulaC19H24N4O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (321.77 mM)
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SMILESO=S(C1=NN(C(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533.
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