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Emixustat
CAS No. 1141777-14-1
Emixustat ( ACU-4429 )
Catalog No. M10502 CAS No. 1141777-14-1
Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 896 | Get Quote |
|
| 100MG | 1566 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEmixustat
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NoteResearch use only, not for human use.
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Brief DescriptionEmixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
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DescriptionEmixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM; reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).Other Indication Phase 3 Clinical
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SynonymsACU-4429
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1141777-14-1
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Formula Weight263.38
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Molecular FormulaC16H25NO2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 43 mg/mL
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SMILESC1CCC(CC1)COC2=CC=CC(=C2)C(CCN)O
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Chemical NameBenzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, (αR)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15.
2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940.
3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.
2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940.
3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.
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