Emixustat ( ACU-4429 )

Catalog No. M10502 CAS No. 1141777-14-1

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.

Purity : >98% (HPLC)

COA

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MSDS

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Biological Information

Product Name

Emixustat
Note

Research use only, not for human use.
Brief Description

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
Description

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM; reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).Other Indication Phase 3 Clinical
Synonyms

ACU-4429
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Other Indications
Indication

Other Disease

Chemical Information

CAS Number

1141777-14-1
Formula Weight

263.38
Molecular Formula

C16H25NO2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 43 mg/mL
SMILES

C1CCC(CC1)COC2=CC=CC(=C2)C(CCN)O
Chemical Name

Benzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, (αR)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15.
2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940.
3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.

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