Emedastine

Research use only, not for human use.

Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity.

Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.

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Others

Other Targets

H1 receptor

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87233-61-2

302.42

C17H26N4O

98%

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CCOCCn1c2ccccc2nc1N1CCCN(CC1)C

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(-20℃)

With Ice Pack

≥ 2 years