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Elatol
CAS No. 55303-97-4
Elatol( NSC 341593 )
Catalog No. M15006 CAS No. 55303-97-4
Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameElatol
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NoteResearch use only, not for human use.
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Brief DescriptionElatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.
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DescriptionElatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types; binds in a 2:1 ratio to eIF4A1 (Kd=1.98 uM) and disrupts helicase activity, Elatol is active against eIF4A1’s ATP hydrolysis at 16.4 uM; Elatol is less potent in vitro than the well-studied eIF4A1 inhibitor silvestrol but is tolerated in vivo at ~100X relative dosing, leading to significant activity against lymphoma xenografts.
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In Vitro——
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In Vivo——
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SynonymsNSC 341593
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PathwayNuclear Receptor/Transcription Factor
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TargeteIF
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RecptoreIF
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Research Area——
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Indication——
Chemical Information
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CAS Number55303-97-4
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Formula Weight333.694
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Molecular FormulaC15H22BrClO
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(CC2(CC1)C(=C)CC(C(C2(C)C)Br)O)Cl
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Chemical Name(3S,4R,6R)-4-bromo-10-chloro-5,5,9-trimethyl-1-methylidenespiro[5.5]undec-9-en-3-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Peters TL, et al. Clin Cancer Res. 2018 May 29. pii: clincanres.3645.2017.
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