Cart
sales@molnova.com
EX-229
CAS No. 1219739-36-2
EX-229 ( EX 229;EX229 )
Catalog No. M10829 CAS No. 1219739-36-2
A small molecule AMPK activator that dose-dependently increases AMPK activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
|
| 5MG | 61 | Get Quote |
|
| 10MG | 102 | Get Quote |
|
| 25MG | 210 | Get Quote |
|
| 50MG | 356 | Get Quote |
|
| 100MG | 536 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameEX-229
-
NoteResearch use only, not for human use.
-
Brief DescriptionA small molecule AMPK activator that dose-dependently increases AMPK activity.
-
DescriptionA small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM; induces AMPK activation and glucose uptak in a wortmannin-independent manner; increases fatty acid oxidation in L6 myotubes.
-
SynonymsEX 229;EX229
-
PathwayMembrane Transporter/Ion Channel
-
TargetAMPK
-
RecptorAMPK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1219739-36-2
-
Formula Weight431.88
-
Molecular FormulaC24H18ClN3O3
-
Purity>98% (HPLC)
-
SolubilityDMSO : 5.4 mg/mL12.50 mM
-
SMILESO=C(O)C1=CC(OC2=NC3=CC(C4=CC5=C(N(C)C=C5)C=C4)=C(Cl)C=C3N2)=CC=C1C
-
Chemical Name5-{[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy}-2-methyl-benzoic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lai YC, et al. Biochem J. 2014 Jun 15;460(3):363-75.
2. Bultot L, et al. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719.
3. Patent WO2010036613, EX229.
2. Bultot L, et al. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719.
3. Patent WO2010036613, EX229.
molnova catalog
related products
-
Metformin hydrochlor...
Metformin Hcl, a widely used anti-diabetic drug has potential efficacy as an anti-Y drug.
-
Gomisin J
Gomisin J is a natural product and have vasodilatory activity.?Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.
-
PF-06409577
PF-06409577(PF06409577, PF 6409577)is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively.
