ETX2514

Research use only, not for human use.

ETX2514 (ETX 2514, ETX-2514)is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively.

ETX2514 (ETX 2514, ETX-2514)is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively; potently inhibit clinically relevant class A, C and D β-lactamases and penicillin-binding proteins, resulting in intrinsic antibacterial activity against Enterobacteriaceae and restoration of β-lactam activity in a broad range of MDR Gram-negative pathogens; demonstrates potent antibacterial activity, in vivo efficacy against MDR A. baumannii infections combined with sulbactam.Bacterial Infection Phase 1 Clinical

ETX 2514;ETX-2514

GPCR/G Protein

Antibacterial

Antibacterial

Infection

Bacterial Infection

1467157-21-6

299.23

C8H10N3NaO6S

>98% (HPLC)

——

CC1=CC2CN(C1C(=O)N)C(=O)N2OS(=O)(=O)[O-].[Na+]

sodium (2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl sulfate

(-20℃)

With Ice Pack

≥ 2 years