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ETX2514
CAS No. 1467157-21-6
ETX2514( ETX 2514 | ETX-2514 )
Catalog No. M12003 CAS No. 1467157-21-6
ETX2514 (ETX 2514, ETX-2514)?is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | In Stock |
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| 5MG | 403 | In Stock |
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| 10MG | 592 | In Stock |
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| 25MG | 888 | In Stock |
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| 50MG | 1242 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameETX2514
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NoteResearch use only, not for human use.
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Brief DescriptionETX2514 (ETX 2514, ETX-2514)?is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively.
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DescriptionETX2514 (ETX 2514, ETX-2514)?is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively; potently inhibit clinically relevant class A, C and D β-lactamases and penicillin-binding proteins, resulting in intrinsic antibacterial activity against Enterobacteriaceae and restoration of β-lactam activity in a broad range of MDR Gram-negative pathogens; demonstrates potent antibacterial activity, in vivo efficacy against MDR A. baumannii infections combined with sulbactam.Bacterial Infection Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsETX 2514 | ETX-2514
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research AreaInfection
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IndicationBacterial Infection
Chemical Information
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CAS Number1467157-21-6
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Formula Weight299.233
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Molecular FormulaC8H10N3NaO6S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC2CN(C1C(=O)N)C(=O)N2OS(=O)(=O)[O-].[Na+]
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Chemical Namesodium (2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl sulfate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Durand-Réville TF, et al. Nat Microbiol. 2017 Jun 30;2:17104.
2. Shapiro AB, et al. ACS Infect Dis. 2017 Nov 10;3(11):833-844.
3. McLeod SM, et al. Antimicrob Agents Chemother. 2017 Nov 13. pii: AAC.01576-17.
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