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Home - Products - MAPK/ERK Signaling - ERK - ERK-IN-3

ERK-IN-3

CAS No. 2055597-12-9

ERK-IN-3( ASN007 free base )

Catalog No. M23920 CAS No. 2055597-12-9

ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ERK-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.
  • Description
    ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ASN007 free base
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    ERK1|ERK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2055597-12-9
  • Formula Weight
    473.93
  • Molecular Formula
    C22H25ClFN7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (527.50 mM; Need ultrasonic)
  • SMILES
    O=C(C1=CN(C2=NC(NC3CCOCC3)=NC=C2C)C=N1)N[C@@H](C4=CC(F)=CC(Cl)=C4)CN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).
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