ER-464195-01 ( ER464195-01 )

Catalog No. M16228 CAS No. 859218-37-4

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Datasheet

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Product Name

ER-464195-01
Note

Research use only, not for human use.
Brief Description

ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT).
Description

ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5; dose-dependently and specificly inhibits GST-fused CRT proteins binding to ITGA4 in vitro pull-down assay; inhibits the PMA-induced T cells and the fMLP-stimulated neutrophils bound to VCAM1 (IC50=0.15 μM) and ICAM-1 (IC50=0.19 μM), respectively; suppresses the cell adhesion and the migration of leukocytes, prevents colitis and downregulates the expression of inflammation-related genes in DSS-treated mice, ameliorates the severity of disease in IBD mouse models.
Synonyms

ER464195-01
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

——
Indication

——

CAS Number

859218-37-4
Formula Weight

379.03
Molecular Formula

C23H39ClN2
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCN1CCN(CC1)C2=CC=CC=C2C3CC(CC(C3)(C)C)(C)C.Cl
Chemical Name

1-propyl-4-(2-(3,3,5,5-tetramethylcyclohexyl)phenyl)piperazine hydrochloride

1. Ohkuro M, et al. Nat Commun. 2018 May 17;9(1):1982.

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