EPZ-011989
CAS No. 1598383-40-4
EPZ-011989 ( EPZ011989 )
Catalog No. M12289 CAS No. 1598383-40-4
EPZ-011989 (EPZ011989)is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 47 | In Stock |
|
10MG | 68 | In Stock |
|
100MG | 344 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameEPZ-011989
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NoteResearch use only, not for human use.
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Brief DescriptionEPZ-011989 (EPZ011989)is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
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DescriptionEPZ-011989 (EPZ011989)is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM; equipotently inhibits mutant and wild-type EZH2, displays >15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTs; demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.Blood Cancer Preclinical
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SynonymsEPZ011989
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorEZH2
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1598383-40-4
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Formula Weight605.81
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Molecular FormulaC35H51N5O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 33 mg/mL
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SMILESO=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C#CCN3CCOCC3)=CC(N(CC)[C@H]4CC[C@H](N(CCOC)C)CC4)=C2C
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Chemical NameBenzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Campbell JE, et al. ACS Med Chem Lett. 2015 Mar 4;6(5):491-5.
2. Gardner EE, et al. Cancer Cell. 2017 Feb 13;31(2):286-299.
2. Gardner EE, et al. Cancer Cell. 2017 Feb 13;31(2):286-299.
molnova catalog
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