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EP009

CAS No. 1462951-30-9

EP009( EP-009 | EP 009 )

Catalog No. M11987 CAS No. 1462951-30-9

A selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    EP009
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
  • Description
    A selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM; exhibits limited off-target effects against a panel of 92 human kinases; inhibits tyrosine phosphorylation and activation of JAK3/STAT3 in SU-DHL-1 cells, with activation of JNK1/2, but not p38; displays a favorable cytotoxicity profile with therapeutic efficacy against JAK3-driven tumor T-cells in vitro, in vivo, and ex vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    EP-009 | EP 009
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1462951-30-9
  • Formula Weight
    224.344
  • Molecular Formula
    C14H24O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(CO)CCCCCCCCCC1=C
  • Chemical Name
    2-(hydroxymethyl)-12-methylenecyclododecanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ross JA, et al. Leukemia. 2014 Apr;28(4):941-4. 2. Martinez GS, et al. Clin Cancer Drugs. 2016;3(2):131-137.
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