EN6 ( —— )

Catalog No. M23822 CAS No. 1808714-73-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

EN6
Note

Research use only, not for human use.
Brief Description

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling.
Description

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy.?EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner.?EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).?
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

1808714-73-9
Formula Weight

368.3
Molecular Formula

C19H14F2N4O2
Purity

>98% (HPLC)
Solubility

DMSO: 4.63 mg/mL (12.57 mM; Need ultrasonic); Ethanol: 1.10 mg/mL (2.99 mM; ultrasonic and warming and heat to 60°C)
SMILES

C=CC(Nc(cc(cc1)NC(c2cn(-c(cccc3)c3F)nc2)=O)c1F)=O
Chemical Name

——

1.Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.

Calculator

molnova catalog