EN6

CAS No. 1808714-73-9

EN6 ( —— )

Catalog No. M23822 CAS No. 1808714-73-9

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 72 In Stock
10MG 125 In Stock
25MG 194 In Stock
50MG 250 In Stock
100MG 380 In Stock
500MG 861 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    EN6
  • Note
    Research use only, not for human use.
  • Brief Description
    EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling.
  • Description
    EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy.?EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner.?EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).?
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1808714-73-9
  • Formula Weight
    368.3
  • Molecular Formula
    C19H14F2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 4.63 mg/mL (12.57 mM; Need ultrasonic); Ethanol: 1.10 mg/mL (2.99 mM; ultrasonic and warming and heat to 60°C)
  • SMILES
    C=CC(Nc(cc(cc1)NC(c2cn(-c(cccc3)c3F)nc2)=O)c1F)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.
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