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EN450
CAS No. 793719-01-4
EN450( —— )
Catalog No. M36937 CAS No. 793719-01-4
EN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a dependence on Cullin E3 ligase and protease, and can be used to study leukemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 59 | Get Quote |
|
| 5MG | 85 | Get Quote |
|
| 10MG | 140 | Get Quote |
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| 25MG | 273 | Get Quote |
|
| 50MG | 419 | Get Quote |
|
| 100MG | 596 | Get Quote |
|
| 500MG | 1233 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEN450
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NoteResearch use only, not for human use.
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Brief DescriptionEN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a dependence on Cullin E3 ligase and protease, and can be used to study leukemia.
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DescriptionEN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number793719-01-4
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Formula Weight288.75
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Molecular FormulaC11H13ClN2O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (346.32 mM; Ultrasonic )
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SMILESO=C(C=C)NC1=CC(=CC=C1Cl)S(=O)(=O)N(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. King EA, et al. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell Chem Biol. 2023 Apr 20;30(4):394-402.e9.?
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