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EN4 MYC inhibitor
CAS No. 1197824-15-9
EN4 MYC inhibitor( EN4 )
Catalog No. M23368 CAS No. 1197824-15-9
EN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
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| 10MG | 80 | In Stock |
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| 25MG | 177 | In Stock |
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| 50MG | 267 | In Stock |
|
| 100MG | 402 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEN4 MYC inhibitor
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NoteResearch use only, not for human use.
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Brief DescriptionEN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.
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DescriptionEN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
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In VitroCell Proliferation Assay Cell Line:231MFP breast cancer cells Concentration:1 μM, 10 μM, 50 μM Incubation Time:72 hours Result:Significantly impaired 231MFP breast cancer cell proliferation in a dose-dependent manner.Western Blot Analysis Cell Line:231MFP breast cancer cells Concentration:50 μM Incubation Time:60 hours Result:The protein levels of CDK2 and CDC25A were significantly lowered.
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In VivoAnimal Model:SCID mice injected with 231MFP breast cancer cells.Dosage:50 mg/kg Administration:Intraperitoneal injection; daily; for 3 weeks Result:Significantly attenuated tumor growth in vivo.
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SynonymsEN4
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PathwayCell Cycle/DNA Damage
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Targetc-Myc
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RecptorMYC
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Research Area——
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Indication——
Chemical Information
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CAS Number1197824-15-9
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Formula Weight416.47
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Molecular FormulaC25H24N2O4
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (600.28 mM; Need ultrasonic)
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SMILESCCOC1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)CNC(=O)C=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lydia Boike, et al. Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17.
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