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EGFR-IN-99
CAS No. 2068806-31-3
EGFR-IN-99( —— )
Catalog No. M34802 CAS No. 2068806-31-3
EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 196 | Get Quote |
|
| 5MG | 302 | Get Quote |
|
| 10MG | 448 | Get Quote |
|
| 25MG | 704 | Get Quote |
|
| 50MG | 966 | Get Quote |
|
| 100MG | 1278 | Get Quote |
|
| 500MG | 2547 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEGFR-IN-99
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NoteResearch use only, not for human use.
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Brief DescriptionEGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC).
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DescriptionEGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetHER/HSP
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RecptorHER | EGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number2068806-31-3
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Formula Weight487.49
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Molecular FormulaC25H22FN7O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C=C)NC1=CC=CC(=C1)N(C(=O)OCC2=CC=C(F)C=C2)C3=NC(=NC=C3)NC=4C=NN(C4)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jang J,et al. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11629-11633.?
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