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EDO-S101
CAS No. 1236199-60-2
EDO-S101 ( EDO-S 101;Tinostamustine )
Catalog No. M10949 CAS No. 1236199-60-2
EDO-S101 (Tinostamustine)is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 186 | In Stock |
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| 50MG | 332 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEDO-S101
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NoteResearch use only, not for human use.
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Brief DescriptionEDO-S101 (Tinostamustine)is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.
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DescriptionEDO-S101 (Tinostamustine)is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat; displays potent activity in vitro in MM cell lines (IC50=1.6-4.8 uM) and ex vivo in cells isolated from MM patients; shows activity in CB17-SCID murine plasmacytoma model and in de novo Vk*MYC mice, also is the only drug with single-agent activity in the multidrug resistant Vk12653 murine model.Blood Cancer Phase 1 Clinical
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SynonymsEDO-S 101;Tinostamustine
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC2;HDAC3;HDAC6;HDAC8
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1236199-60-2
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Formula Weight415.36
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Molecular FormulaC19H28Cl2N4O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESCN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCCCCC(=O)NO
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Chemical Name1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mehrling T, et al. Anticancer Agents Med Chem. 2016;16(1):20-8.
2. López-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20;10(1):127.
3. Besse L, et al. Blood Cancer J. 2017 Jul 28;7(7):e589.
2. López-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20;10(1):127.
3. Besse L, et al. Blood Cancer J. 2017 Jul 28;7(7):e589.
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