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EB1
CAS No. 42951-68-8
EB1( —— )
Catalog No. M36547 CAS No. 42951-68-8
EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 103 | In Stock |
|
| 5MG | 155 | In Stock |
|
| 10MG | 226 | In Stock |
|
| 25MG | 363 | In Stock |
|
| 50MG | 546 | In Stock |
|
| 100MG | 761 | In Stock |
|
| 500MG | 2115 | In Stock |
|
| 1G | 3141 | In Stock |
|
Biological Information
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Product NameEB1
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NoteResearch use only, not for human use.
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Brief DescriptionEB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.
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DescriptionEB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation.
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In VitroWestern Blot Analysis Cell Line:MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells Concentration:1.3 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:24 hours Result:Blocked the phosphorylation of eIF4E in a dose-dependent manner.Apoptosis Analysis Cell Line:MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:72 hours Result:Increased the percentage of apoptosis cells among tumor cells.
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetMNK
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RecptorMNK
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Research Area——
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Indication——
Chemical Information
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CAS Number42951-68-8
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Formula Weight286.33
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Molecular FormulaC18H14N4
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Purity>98% (HPLC)
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Solubility——
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SMILESNC=1C2=C(C=C(N=C2NN1)C3=CC=CC=C3)C4=CC=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bou-Petit E, et al. Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor. J Med Chem. 2022 Apr 28;65(8):6070-6087. ?
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