EB-47

CAS No. 366454-36-6

EB-47 ( —— )

Catalog No. M26189 CAS No. 366454-36-6

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 120 Get Quote
10MG 201 Get Quote
25MG 357 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    EB-47
  • Note
    Research use only, not for human use.
  • Brief Description
    EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM.
  • Description
    EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.(In Vitro):The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%.(In Vivo):EB-47 (2 μM;?5 days) decreases the number of embryo implantation sites and blastocysts at day 5.PARP1 participates in the process of embryo implantation.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT1A; 5-HT2A; D2 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    366454-36-6
  • Formula Weight
    537.5
  • Molecular Formula
    C24H27N9O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(=O)Nc2cccc3C(=O)NCc23)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jann MW, et al. Long-Acting Injectable Second-Generation Antipsychotics:An Update and Comparison Between Agents.CNS Drugs. 2018 Mar;32(3):241-257.
molnova catalog
related products
  • Vorapaxar sulfate

    Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.

  • BIBF0775

    BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).

  • 3-Methoxydaidzein

    3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively.