EB-47( —— )

Catalog No. M26189 CAS No. 366454-36-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

EB-47
Note

Research use only, not for human use.
Brief Description

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM.
Description

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.(In Vitro):The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%.(In Vivo):EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5.PARP1 participates in the process of embryo implantation.
In Vitro

EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0?μM, respectively.
In Vivo

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

5-HT1A| 5-HT2A| D2 receptor
Research Area

——
Indication

——

CAS Number

366454-36-6
Formula Weight

537.537
Molecular Formula

C24H27N9O6
Purity

>98% (HPLC)
Solubility

——
SMILES

Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(=O)Nc2cccc3C(=O)NCc23)CC1
Chemical Name

——

1.Jann MW, et al. Long-Acting Injectable Second-Generation Antipsychotics:An Update and Comparison Between Agents.CNS Drugs. 2018 Mar;32(3):241-257.

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