EB-47
CAS No. 366454-36-6
EB-47 ( —— )
Catalog No. M26189 CAS No. 366454-36-6
EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 120 | Get Quote |
|
10MG | 201 | Get Quote |
|
25MG | 357 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEB-47
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NoteResearch use only, not for human use.
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Brief DescriptionEB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM.
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DescriptionEB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.(In Vitro):The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%.(In Vivo):EB-47 (2 μM;?5 days) decreases the number of embryo implantation sites and blastocysts at day 5.PARP1 participates in the process of embryo implantation.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor5-HT1A; 5-HT2A; D2 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number366454-36-6
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Formula Weight537.5
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Molecular FormulaC24H27N9O6
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Purity>98% (HPLC)
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Solubility——
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SMILESNc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(=O)Nc2cccc3C(=O)NCc23)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jann MW, et al. Long-Acting Injectable Second-Generation Antipsychotics:An Update and Comparison Between Agents.CNS Drugs. 2018 Mar;32(3):241-257.
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