EB-47

CAS No. 366454-36-6

EB-47 ( —— )

Catalog No. M26189 CAS No. 366454-36-6

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    EB-47
  • Note
    Research use only, not for human use.
  • Brief Description
    EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM.
  • Description
    EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.(In Vitro):The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%.(In Vivo):EB-47 (2 μM;?5 days) decreases the number of embryo implantation sites and blastocysts at day 5.PARP1 participates in the process of embryo implantation.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT1A; 5-HT2A; D2 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    366454-36-6
  • Formula Weight
    537.5
  • Molecular Formula
    C24H27N9O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(=O)Nc2cccc3C(=O)NCc23)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jann MW, et al. Long-Acting Injectable Second-Generation Antipsychotics:An Update and Comparison Between Agents.CNS Drugs. 2018 Mar;32(3):241-257.
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