Dup-721

CAS No. 104421-21-8

Dup-721 ( —— )

Catalog No. M28176 CAS No. 104421-21-8

DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 69 Get Quote
5MG 115 Get Quote
10MG 192 Get Quote
25MG 394 Get Quote
50MG 584 Get Quote
100MG 833 Get Quote
500MG 1683 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Dup-721
  • Note
    Research use only, not for human use.
  • Brief Description
    DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.
  • Description
    DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.(In Vitro):DuP-721 (1.5-4 μg/ml) inhibits equally the strains of Mycobacterium tuberculosis susceptible and resistant to conventional antituberculosis drug. And it does not show cross resistance to any of the anti-tuberculosis drugs tested.DuP-721 is inactive against M. avium and M. intracellulare at 250 μg/ml. It inhibits M. gordonoe and M. fortuitum at 3.9 μg/ml and M. kansassi and M. scrofulaceum at 1.95 μg/ml and 15.6 μg/ml, respectively.(In Vivo):DuP-721 (oral gavage; 50-160 mg/kg) is protective against M. tuberculosis infection in mice. DuP-721 protects 100% of the infected animals at 50 mg/kg p.o. dose when administered daily for 17 days, and the same effect is observed at 160 mg/kg dose when the drug is administered only on day 11 and 12 post infection.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Nuclear factor of activated Tcells (NFAT)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    104421-21-8
  • Formula Weight
    276.3
  • Molecular Formula
    C14H16N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N/A
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Colin A Bretz,?et al. The role of the NFAT signaling pathway in retinal neovascularization. Invest Ophthalmol Vis Sci.?2013 Oct 25;54(10):7020-7.
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