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Droxinostat

CAS No. 99873-43-5

Droxinostat ( NS 41080;NS-41080;NS41080 )

Catalog No. M16918 CAS No. 99873-43-5

Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Droxinostat
  • Note
    Research use only, not for human use.
  • Brief Description
    Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.
  • Description
    Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively; does not inhibit HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, HDAC9, and HDAC10 with IC50 of >20 uM; sensitizes malignant cells to death receptor ligands FAS and TRAIL sensitization with IC50 of 20 and 39 uM, respectively; decreases the expression of the caspase-8 inhibitor FLIP, downregulates c-FLIP(L) and c-FLIP(S) mRNA and protein levels, causes PARP degradation, reduces cell survival, and induces apoptosis in MCF-7 breast cancer cells.
  • Synonyms
    NS 41080;NS-41080;NS41080
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC10;HDAC3;HDAC6;HDAC8;HDAC9
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    99873-43-5
  • Formula Weight
    243.70
  • Molecular Formula
    C11H14ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NO)CCCOC1=CC=C(Cl)C=C1C
  • Chemical Name
    Butanamide, 4-(4-chloro-2-methylphenoxy)-N-hydroxy-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wood TE, et al. Mol Cancer Ther. 2010 Jan;9(1):246-56.
2. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem. 2010 Sep;342(1-2):133-142.
3. McCourt C, et al. Clin Cancer Res. 2012 Jul 15;18(14):3822-33.
4. Liu J, et al. Transl Oncol. 2016 Feb;9(1):70-78.
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