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DprE1-IN-25

CAS No. 1615713-87-5

DprE1-IN-25( MDK3875 | MDK-3875 | MDK 3875 | DprE1-IN-2 | DprE1IN2 )

Catalog No. M12351 CAS No. 1615713-87-5

A potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DprE1-IN-25
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
  • Description
    A potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
  • In Vitro
    ——
  • In Vivo
    DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice. Animal Model:BALB/c Mice Dosage:100 mg/kg Administration:Oral Result:Had t1/2 of 0.9 hours and Cmax of 70 μM.
  • Synonyms
    MDK3875 | MDK-3875 | MDK 3875 | DprE1-IN-2 | DprE1IN2
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    DprE
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1615713-87-5
  • Formula Weight
    368.4329
  • Molecular Formula
    C19H24N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    O=C(C1=CN(CC2=NC=NC(N(C)C)=C2C)C3=CC(C)=CN=C31)NCCO
  • Chemical Name
    1H-Pyrrolo[3,2-b]pyridine-3-carboxamide, 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shirude PS, et al. J Med Chem. 2014 Jul 10;57(13):5728-37.
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