DprE1-IN-25( MDK3875 | MDK-3875 | MDK 3875 | DprE1-IN-2 | DprE1IN2 )

Catalog No. M12351 CAS No. 1615713-87-5

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Datasheet

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Product Name

DprE1-IN-25
Note

Research use only, not for human use.
Brief Description

A potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
Description

A potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
In Vitro

——
In Vivo

DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice. Animal Model:BALB/c Mice Dosage:100 mg/kg Administration:Oral Result:Had t1/2 of 0.9 hours and Cmax of 70 μM.
Synonyms

MDK3875 | MDK-3875 | MDK 3875 | DprE1-IN-2 | DprE1IN2
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

DprE
Research Area

Cancer
Indication

——

CAS Number

1615713-87-5
Formula Weight

368.4329
Molecular Formula

C19H24N6O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 33 mg/mL
SMILES

O=C(C1=CN(CC2=NC=NC(N(C)C)=C2C)C3=CC(C)=CN=C31)NCCO
Chemical Name

1H-Pyrrolo[3,2-b]pyridine-3-carboxamide, 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-

1. Shirude PS, et al. J Med Chem. 2014 Jul 10;57(13):5728-37.

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