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Dooku1
CAS No. 2253744-54-4
Dooku1( —— )
Catalog No. M26169 CAS No. 2253744-54-4
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
|
| 5MG | 80 | In Stock |
|
| 10MG | 129 | In Stock |
|
| 25MG | 259 | In Stock |
|
| 50MG | 482 | In Stock |
|
| 100MG | 696 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDooku1
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NoteResearch use only, not for human use.
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Brief DescriptionDooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels.
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DescriptionDooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.
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In VitroCell Viability Assay Cell Line:HUVECs, Piezo1 T-REx cells Concentration:10 μM Incubation Time:40-60 s Result:Had a concentration-dependent inhibitory effect against Yoda1-induced Ca2+ entry in HUVECs, acting with an IC50 of 1.49 μM.Increased potency in HUVECs with an EC50 of 0.23 μM, compared with 2.51 μM in Piezo1 T-REx cells.
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In VivoAnimal Model:wild-type male C57BL/6 mice’s aortic rings Dosage:10 μM Administration:20 min Result:Suppressed the Yoda1-induced relaxation.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorBacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number2253744-54-4
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Formula Weight326.2
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Molecular FormulaC13H9Cl2N3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (306.56 mM)
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SMILESClc1cccc(Cl)c1CSc1nnc(o1)-c1ccc[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Alois Pískala, et al. Synthesis, molecular conformation and biological activity of 6-amino-5-azacytidine. Collect. Czech. Chem. Commun. 1989, 54, 2502-2512.
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