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Dinaciclib
CAS No. 779353-01-4
Dinaciclib ( SCH 727965;SCH727965;SCH-727965 )
Catalog No. M15942 CAS No. 779353-01-4
A potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 109 | In Stock |
|
| 50MG | 348 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDinaciclib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
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DescriptionA potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively; completely suppresses Rb phosphorylation and inhibits bromodeoxyuridine incorporation in >100 tumor cell lines; exhibits superior activity with an improved therapeutic index compared with flavopiridol.Blood Cancer Phase 3 Clinical
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SynonymsSCH 727965;SCH727965;SCH-727965
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1;CDK2;CDK5;CDK9
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number779353-01-4
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Formula Weight396.49
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Molecular FormulaC21H28N6O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 56 mg/mL
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SMILESOCC[C@H]1N(C2=NC3=C(CC)C=NN3C(NCC4=C[N+]([O-])=CC=C4)=C2)CCCC1
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Chemical Name2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Parry D, et al. Mol Cancer Ther. 2010 Aug;9(8):2344-53.
2. Paruch K, et al. ACS Med Chem Lett. 2010 May 17;1(5):204-8.
3. Feldmann G, et al. Cancer Biol Ther. 2011 Oct 1;12(7):598-609.
4. Johnson AJ, et al. Leukemia. 2012 Dec;26(12):2554-7.
2. Paruch K, et al. ACS Med Chem Lett. 2010 May 17;1(5):204-8.
3. Feldmann G, et al. Cancer Biol Ther. 2011 Oct 1;12(7):598-609.
4. Johnson AJ, et al. Leukemia. 2012 Dec;26(12):2554-7.
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