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Dinaciclib

CAS No. 779353-01-4

Dinaciclib ( SCH 727965;SCH727965;SCH-727965 )

Catalog No. M15942 CAS No. 779353-01-4

A potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dinaciclib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
  • Description
    A potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively; completely suppresses Rb phosphorylation and inhibits bromodeoxyuridine incorporation in >100 tumor cell lines; exhibits superior activity with an improved therapeutic index compared with flavopiridol.Blood Cancer Phase 3 Clinical
  • Synonyms
    SCH 727965;SCH727965;SCH-727965
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK1;CDK2;CDK5;CDK9
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    779353-01-4
  • Formula Weight
    396.49
  • Molecular Formula
    C21H28N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 56 mg/mL
  • SMILES
    OCC[C@H]1N(C2=NC3=C(CC)C=NN3C(NCC4=C[N+]([O-])=CC=C4)=C2)CCCC1
  • Chemical Name
    2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Parry D, et al. Mol Cancer Ther. 2010 Aug;9(8):2344-53.
2. Paruch K, et al. ACS Med Chem Lett. 2010 May 17;1(5):204-8.
3. Feldmann G, et al. Cancer Biol Ther. 2011 Oct 1;12(7):598-609.
4. Johnson AJ, et al. Leukemia. 2012 Dec;26(12):2554-7.
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