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Dimethylfraxetin

CAS No. 6035-49-0

Dimethylfraxetin( 678-Trimethoxycoumarin | Fraxetin dimethyl ether )

Catalog No. M20278 CAS No. 6035-49-0

Dimethylfraxetin is a?Carbonic anhydrase?inhibitor（Ki：0.0097 μM）

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dimethylfraxetin
  • Note
    Research use only, not for human use.
  • Brief Description
    Dimethylfraxetin is a?Carbonic anhydrase?inhibitor（Ki：0.0097 μM）
  • Description
    Dimethylfraxetin is a?Carbonic anhydrase?inhibitor.（Ki：0.0097 μM）.
  • In Vitro
    At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study.
  • In Vivo
    ——
  • Synonyms
    678-Trimethoxycoumarin | Fraxetin dimethyl ether
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Carbonic Anhydrase
  • Recptor
    Carbonic Anhydrase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6035-49-0
  • Formula Weight
    236.22
  • Molecular Formula
    C12H12O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(529.17 mM)
  • SMILES
    COc1cc2ccc(=O)oc2c(OC)c1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Davis R A Vullo D Maresca A et al. Natural product coumarins that inhibit human carbonic anhydrases[J]. Bioorganic & medicinal chemistry 2012 21(6):1539-1543.
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