Dienogest

Research use only, not for human use.

Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.

Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.

Cell Viability Assay Cell Line:EM-PR cells Concentration:0.01-1 μM Incubation Time:24 h Result:Inhibited PGE2 production and suppressed NF-κB binding activity in the spheroid culture. Cell Viability Assay Cell Line:EM-PR cells Concentration:0.1 μM Incubation Time:24 h Result:Decreased the mRNA expression of the PGE2 synthases COX-2 and mPGES-1 compared with the respective control.Inhibited aromatase mRNA expression and increased the expression of COUP-TFII mRNA level.

Animal Model:Female Wistar rats (8 to 10-week-old; 180-220 g; rat endometrial autograft model).Dosage:1 mg/kg Administration:Oral administration; once daily for 14 days.Result:Showed significant suppression of angiogenesis of endometrial autografts, as indicated by the reduced size of the microvascular network and decreased microvessel density.Significantly reduced the level of perivascular α-smooth muscle actin within endometrial grafts.

STS 557

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Endocrinology

——

65928-58-7

311.42

C20H25NO2

>98% (HPLC)

DMSO: 62 mg/mL (199.08 mM)

N#CC[C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3CC[C@]12C)=O

2-((8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile

(-20℃)

With Ice Pack

≥ 2 years