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Didymin

CAS No. 14259-47-3

Didymin( —— )

Catalog No. M18013 CAS No. 14259-47-3

Didymin has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Didymin
  • Note
    Research use only, not for human use.
  • Brief Description
    Didymin has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy.
  • Description
    Didymin has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy. Didymin may be a potential therapeutic molecule for the treatment of neurodegenerative disorders associated with oxidative stress.
  • In Vitro
    Cell Proliferation Assay Cell Line:A549 and H460 cells Concentration:1 μM, 5 μM, 10 μM, 20 μM Incubation Time:48 h Result:Inhibited cell proliferation in human non-small-cell lung cancer cells.Apoptosis Analysis Cell Line:A549 and H460 cells Concentration:10 μM, 20 μM Incubation Time:12 h, 24 h, 48 h Result:Induced apoptosis in A549 and H460 cells, without affecting the cell cycle distribution.
  • In Vivo
    Animal Model:Male nude mice [6 weeks old; BALB/cA-nu (nu/nu)] injected with A549 cells Dosage:6 mg/kg/day Administration:i.p.; daily for 28 days Result:Inhibited tumor growth in nude mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    14259-47-3
  • Formula Weight
    594.57
  • Molecular Formula
    C28H34O14
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (420.48 mM)
  • SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)Oc1cc(c2C(=O)C[C@H](Oc2c1)c1ccc(cc1)OC)O)O)O)O)O)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Morelli S, et al. Neuroprotective effect of didymin on hydrogen peroxide-induced injury in the neuronal membrane system. Cells Tissues Organs. 2014;199(2-3):184-200.
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