Diarylpropionitrile

Research use only, not for human use.

Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand.

Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture; (1-100 nM) significantly decreases neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2; decreases the expression levels of IL-1β and IL-6; inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.

DPN

Endocrinology/Hormones

Estrogen Receptor/ERR

Estrogen Receptor/ERR

Neurological Disease

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1428-67-7

239.27

C15H13NO2

>98% (HPLC)

10 mM in DMSO

C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O

Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-

(-20℃)

With Ice Pack

≥ 2 years