Dianemycin

CAS No. 35865-33-9

Dianemycin( Nanchangmycin (free acid) )

Catalog No. M21964 CAS No. 35865-33-9

Dianemycin is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 81 Get Quote
5MG 125 Get Quote
10MG 208 Get Quote
50MG 619 Get Quote
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Biological Information

  • Product Name
    Dianemycin
  • Note
    Research use only, not for human use.
  • Brief Description
    Dianemycin is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria.
  • Description
    Dianemycin is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria.?Nanchangmycin is a broad spectrum antiviral active against Zika virus
  • In Vitro
    Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria. Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types.
  • In Vivo
    ——
  • Synonyms
    Nanchangmycin (free acid)
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    35865-33-9
  • Formula Weight
    867.11
  • Molecular Formula
    C47H78O14
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/ml(172.99 mM; Need ultrasonic)
  • SMILES
    [H][C@@]1(C[C@H](O[C@@H]2CC[C@H](OC)[C@@H](C)O2)[C@@H](C)[C@@]2(O[C@H](C[C@@H]2C)[C@@]2([H])O[C@@](O)(CO)[C@H](C)C[C@@H]2C)O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@]([H])(O2)[C@@H](C)\C=C(/C)C(=O)[C@H](C)C[C@H](C)C(O)=O)O1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hamill R L , Hoenh M M , Pittenger G E , et al. DIANEMYCIN, AN ANTIBIOTIC OF THE GROUP AFFECTING ION TRANSPORT[J]. The Journal of Antibiotics, 1969, 22(4):161-164.2. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.3. Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58.
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