Dianemycin
CAS No. 35865-33-9
Dianemycin( Nanchangmycin (free acid) )
Catalog No. M21964 CAS No. 35865-33-9
Dianemycin is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 81 | Get Quote |
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5MG | 125 | Get Quote |
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10MG | 208 | Get Quote |
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50MG | 619 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameDianemycin
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NoteResearch use only, not for human use.
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Brief DescriptionDianemycin is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria.
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DescriptionDianemycin is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria.?Nanchangmycin is a broad spectrum antiviral active against Zika virus
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In VitroDianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria. Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types.
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In Vivo——
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SynonymsNanchangmycin (free acid)
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorBacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number35865-33-9
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Formula Weight867.11
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Molecular FormulaC47H78O14
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/ml(172.99 mM; Need ultrasonic)
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SMILES[H][C@@]1(C[C@H](O[C@@H]2CC[C@H](OC)[C@@H](C)O2)[C@@H](C)[C@@]2(O[C@H](C[C@@H]2C)[C@@]2([H])O[C@@](O)(CO)[C@H](C)C[C@@H]2C)O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@]([H])(O2)[C@@H](C)\C=C(/C)C(=O)[C@H](C)C[C@H](C)C(O)=O)O1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hamill R L , Hoenh M M , Pittenger G E , et al. DIANEMYCIN, AN ANTIBIOTIC OF THE GROUP AFFECTING ION TRANSPORT[J]. The Journal of Antibiotics, 1969, 22(4):161-164.2. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.3. Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58.
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