Dexrazoxane( ICRF-187 | NSC-169780 )

Catalog No. M13714 CAS No. 24584-09-6

A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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50MG	51	In Stock
100MG	73	In Stock
500MG	180	In Stock
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Biological Information

Product Name

Dexrazoxane
Note

Research use only, not for human use.
Brief Description

A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals.
Description

A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals; protects the heart against the cardiotoxic side effects of chemotherapeutic drugs.Chemotherapeutic Agents Approved
In Vitro

——
In Vivo

——
Synonyms

ICRF-187 | NSC-169780
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Cancer
Indication

Chemotherapeutic

Chemical Information

CAS Number

24584-09-6
Formula Weight

268.2691
Molecular Formula

C11H16N4O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C[C@H](N(C1)CC(NC1=O)=O)CN(C2)CC(NC2=O)=O
Chemical Name

2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lipshultz SE, et al. N Engl J Med. 2004 Jul 8;351(2):145-53. 2. Bjelogrlic SK, et al. Exp Biol Med (Maywood). 2007 Dec;232(11):1414-24. 3. Jones RL, et al. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7.

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