Dermofongin

CAS No. 130-16-5

Dermofongin( —— )

Catalog No. M11211 CAS No. 130-16-5

5-Chloro-8-hydroxyquinoline, also called Cloxiquine, has the efficancy of anti-viral.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dermofongin
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Chloro-8-hydroxyquinoline, also called Cloxiquine, has the efficancy of anti-viral.
  • Description
    5-Chloro-8-hydroxyquinoline, also called Cloxiquine, has the efficancy of anti-viral.(In Vitro):Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis.Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.(In Vivo):Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.
  • In Vitro
    Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis.Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.
  • In Vivo
    Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    130-16-5
  • Formula Weight
    179.6
  • Molecular Formula
    C9H6ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    OC1=C2N=CC=CC2=C(Cl)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Latosińska JN, et al. J Mol Model. 2011 Jul;17(7):1781-800.
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