Dermaseptin

Research use only, not for human use.

Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.

Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.(In Vitro):Dermaseptin is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration. Circular dichroism spectra of dermaseptin in hydrophobic media indicated 80% alpha-helical conformation, and predictions of secondary structure suggested that dermaseptin can be configured as an amphiphatic alpha-helix spanning over residues 1-27, a structure that perturbs membrane functions regulating water flux. Dermaseptin exerts a lytic action upon bacteria, protozoa, yeasts, and filamentous fungi at micromolar concentrations. Molecular elements responsible for the exceptional antimicrobial potency of dermaseptin are to be traced to the NH2-terminal alpha-helical amphipathic segment spanning residues 1-18 of the molecule.

GPCR/G Protein

Antibacterial

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136212-91-4

3455.1

C152H257N43O44S2

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years