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Derenofylline
CAS No. 251945-92-3
Derenofylline( —— )
Catalog No. M21579 CAS No. 251945-92-3
Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 63 | In Stock |
|
| 10MG | 104 | In Stock |
|
| 25MG | 228 | In Stock |
|
| 50MG | 410 | In Stock |
|
| 100MG | 591 | In Stock |
|
| 200MG | 804 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDerenofylline
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NoteResearch use only, not for human use.
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Brief DescriptionDerenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
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DescriptionDerenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
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In Vitro——
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In VivoAnimal Model:5/6 nephrectomy rats Dosage:10 mg/kg/d Administration:Oral administration, mixed with food for 12 weeks Result:Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.
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Synonyms——
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorA1
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Research AreaCardiovascular Disease
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IndicationCongestive Heart Failure
Chemical Information
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CAS Number251945-92-3
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Formula Weight308.38
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Molecular FormulaC18H20N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (324.28 mM)
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SMILESO[C@H]1CC[C@@H](CC1)Nc1nc(nc2[nH]ccc12)-c1ccccc1
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Chemical Name(1r4r)-4-((2-phenyl-1H-pyrrolo[23-d]pyrimidin-4-yl)amino)cyclohexan-1-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kalk P et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.
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