Derenofylline

CAS No. 251945-92-3

Derenofylline( —— )

Catalog No. M21579 CAS No. 251945-92-3

Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 63 In Stock
10MG 104 In Stock
25MG 228 In Stock
50MG 410 In Stock
100MG 591 In Stock
200MG 804 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Derenofylline
  • Note
    Research use only, not for human use.
  • Brief Description
    Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
  • Description
    Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:5/6 nephrectomy rats Dosage:10 mg/kg/d Administration:Oral administration, mixed with food for 12 weeks Result:Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    A1
  • Research Area
    Cardiovascular Disease
  • Indication
    Congestive Heart Failure

Chemical Information

  • CAS Number
    251945-92-3
  • Formula Weight
    308.38
  • Molecular Formula
    C18H20N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (324.28 mM)
  • SMILES
    O[C@H]1CC[C@@H](CC1)Nc1nc(nc2[nH]ccc12)-c1ccccc1
  • Chemical Name
    (1r4r)-4-((2-phenyl-1H-pyrrolo[23-d]pyrimidin-4-yl)amino)cyclohexan-1-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kalk P et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.
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