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Derenofylline

CAS No. 251945-92-3

Derenofylline( —— )

Catalog No. M21579 CAS No. 251945-92-3

Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Derenofylline
  • Note
    Research use only, not for human use.
  • Brief Description
    Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
  • Description
    Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:5/6 nephrectomy rats Dosage:10 mg/kg/d Administration:Oral administration, mixed with food for 12 weeks Result:Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    A1
  • Research Area
    Cardiovascular Disease
  • Indication
    Congestive Heart Failure

Chemical Information

  • CAS Number
    251945-92-3
  • Formula Weight
    308.38
  • Molecular Formula
    C18H20N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (324.28 mM)
  • SMILES
    O[C@H]1CC[C@@H](CC1)Nc1nc(nc2[nH]ccc12)-c1ccccc1
  • Chemical Name
    (1r4r)-4-((2-phenyl-1H-pyrrolo[23-d]pyrimidin-4-yl)amino)cyclohexan-1-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kalk P et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.
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