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Depofemin

CAS No. 313-06-4

Depofemin( Estradiol cypionate | β-Estradiol 17-cypionate )

Catalog No. M14003 CAS No. 313-06-4

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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200MG 28 In Stock
500MG 41 In Stock
1G 71 In Stock
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Biological Information

  • Product Name
    Depofemin
  • Note
    Research use only, not for human use.
  • Brief Description
    Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
  • Description
    Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
  • In Vitro
    Western Blot Analysis Cell Line:MGC803, SGC7901, and BGC823 cells Concentration:10-25 μM Incubation Time:48 h Result:Increased protein level of cleaved caspase-3 and PARP.Decreased protein levels of AKT, p-AKT, p-mTOR, p-S6K, and p-4E-BP1.
  • In Vivo
    Animal Model:MGC803 nude mice tumor model.Dosage:50-100?mg/kg Administration:i.p., every other day Result:Inhibited tumor growth.Increased Cleaved caspase-3 expression, decreased Ki67, AKT and p-AKT in tumors.
  • Synonyms
    Estradiol cypionate | β-Estradiol 17-cypionate
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    ER
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    313-06-4
  • Formula Weight
    396.58
  • Molecular Formula
    C26H36O3
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 55 mg/mL (138.69 mM); DMSO: 79 mg/mL (199.21 mM)
  • SMILES
    O=C(O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC[C@]12C)CCC5CCCC5
  • Chemical Name
    Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17beta-yl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Oriowo MA, et al. Contraception, 1980, 21(4), 415-424.
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