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Deltonin

CAS No. 55659-75-1

Deltonin( —— )

Catalog No. M19433 CAS No. 55659-75-1

Deltonin has an inhibition of ERK1/2 and AKT activation.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Deltonin
  • Note
    Research use only, not for human use.
  • Brief Description
    Deltonin has an inhibition of ERK1/2 and AKT activation.
  • Description
    Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM) mouse C26 cells (IC50: 1.22 μM) and human MDA-MB-231 cells (IC50: 1.58 μM).
  • In Vitro
    Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC50s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells.Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA-MB-231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA-MB-231 cells.
  • In Vivo
    Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55659-75-1
  • Formula Weight
    885.05
  • Molecular Formula
    C45H72O17
  • Purity
    >98% (HPLC)
  • Solubility
    Water
  • SMILES
    O[C@@H]9[C@H](O)[C@@H](O)[C@H](C)O[C@H]9O[C@@H]8[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@@H](CO)O[C@H]8O[C@@H]6CC7=CC[C@@H]3[C@H](CC[C@]4(C)[C@H]5[C@H](C)[C@@]2(CC[C@@H](C)CO2)O[C@H]5C[C@@H]34)[C@@]7(C)CC6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tong QY et al. Deltonin a steroidal saponin inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42.
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