Dehydromiltirone( —— )

Catalog No. M30947 CAS No. 116064-77-8

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Product Name

Dehydromiltirone
Note

Research use only, not for human use.
Brief Description

Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF-κB signaling pathway.
Description

Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF-κB signaling pathway.
In Vitro

Western Blot Analysis Cell Line:Kupffer cells Concentration:100?μg/mL Incubation Time:For 24?h Result:Significantly decreased p38 and p-p38 levels, NF-κBp65, IκB, andc-fos protein levels.
In Vivo

Animal Model:Rat model of acute liver injury Dosage:50 mg/kg, 100 mg/kg, and 200?mg/kg Administration:p.o.; daily; for five consecutive days Result:Protected liver from CCl4-induced damage.
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