Dacarbazine

Research use only, not for human use.

Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various Ys, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas.

Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various Ys, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas.

Cell Viability Assay Cell Line:A375, MNT-1 Concentration:6.25, 12.5, 25, 50, 100, 200, 400, 500 μg/mL Incubation Time:24, 48, 72 h Result:Inhibited cell viability in a concentration-dependent manner.Cell Cycle Analysis Cell Line:A375, MNT-1 Concentration:5.5, 115 μg/mL Incubation Time:48 h Result:Decreased (9.3%) the percentage of A375 cells at the S phase and increased the number of cells at G2/M.Decreased MNT-1 cells at G0/G1, increasing in cells at both S and G2/M phases.

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NCI C04717 | NSC 45388

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA polymerase beta

Cancer

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4342-03-4

182.18

C6H10N6O

>98% (HPLC)

DMSO: 3 mg/mL (16.46 mM)

O=C(C1=C(/N=N/N(C)C)NC=N1)N

(E)-5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide

(-20℃)

With Ice Pack

≥ 2 years