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DZD9008
CAS No. 2370013-49-1
DZD9008( N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide )
Catalog No. M24086 CAS No. 2370013-49-1
DZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 125 | In Stock |
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| 10MG | 200 | In Stock |
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| 25MG | 402 | In Stock |
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| 50MG | 593 | In Stock |
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| 100MG | 845 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDZD9008
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NoteResearch use only, not for human use.
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Brief DescriptionDZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
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DescriptionDZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
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In Vitro(S)-Sunvozertinib shows proliferation inhibition of Ba/F3 EGFR NPH ins (GI50=139.7 nM), Ba/F3 FGFR ASV ins (155.7 nM), NCI-HI975 EGFRL858R/T790M (24.4), Her2 YVMA ins (827 nM) and WT EGFR (84.8 nM).(S)-Sunvozertinib shows proliferation inhibition of BTK WT cells (OCI-LY-10, TMD-8, Ri-1and DB, with GI50 ranging from 13.7-48 nM).
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In Vivo——
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SynonymsN-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide
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PathwayAngiogenesis
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TargetHER/HSP
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RecptorEGFR/HER2
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Research Area——
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Indication——
Chemical Information
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CAS Number2370013-49-1
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Formula Weight584.09
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Molecular FormulaC29H35ClFN7O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (85.60 mM)
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SMILESCC(C)(c(c(Nc1nc(Nc(cc(c(N(CC2)C[C@H]2N(C)C)c2)NC(C=C)=O)c2OC)ncc1)c1)cc(F)c1Cl)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhou Q , Gan B , Hong Q , et al. JCES01.17 A Phase I Dose Expansion Study of Epitinib to Evaluate Efficacy and Safety in EGFR Mutation Positive (EGFRm+) NSCLC Patients with Brain Metastasis[J]. Journal of Thoracic Oncology, 2017, 12(1):S236-S237.
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