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DX3-213B

CAS No. 2749555-66-4

DX3-213B( —— )

Catalog No. M35700 CAS No. 2749555-66-4

DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DX3-213B
  • Note
    Research use only, not for human use.
  • Brief Description
    DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM.
  • Description
    DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC50=3.6 nM). DX3-213B impairs ATP generation (IC50=11 nM), and blocks MIA PaCa-2 cell growth (GI50=11 nM). DX3-213B is used for the research of the pancreatic cancer.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    OXPHOS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2749555-66-4
  • Formula Weight
    478.57
  • Molecular Formula
    C20H28F2N2O5S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (261.19 mM; Ultrasonic (<60°C)
  • SMILES
    CC(C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)N1CCC[C@H](C1)C(=O)N1CCC(F)(F)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xue D, et al. Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer. J Med Chem. 2022;65(4):3404-3419. ?
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