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DUPA(OtBu)-OH
CAS No. 1026987-94-9
DUPA(OtBu)-OH( —— )
Catalog No. M23230 CAS No. 1026987-94-9
DUPA(OtBu)-OH is a DUPA precursor.
DUPA(OtBu)-OH is a DUPA precursor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | In Stock |
|
| 10MG | 205 | In Stock |
|
| 25MG | 340 | In Stock |
|
| 50MG | 484 | In Stock |
|
| 100MG | 680 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDUPA(OtBu)-OH
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NoteResearch use only, not for human use.
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Brief DescriptionDUPA(OtBu)-OH is a DUPA precursor.
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DescriptionDUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
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In VitroDUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells.
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In VivoDUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1026987-94-9
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Formula Weight488.57
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Molecular FormulaC23H40N2O9
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (255.85 mM; Need ultrasonic)
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SMILESCC(C)(C)OC(=O)CC[C@@H](C(=O)OC(C)(C)C)NC(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selectiveprostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103.
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