DTP3( —— )

Catalog No. M23824 CAS No. 1809784-29-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DTP3
Note

Research use only, not for human use.
Brief Description

DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
Description

DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
In Vitro

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In Vivo

Animal Model:6 to 8-week old male NOD/SCID mice (NOD.CB17-Prkdcscid/IcrCrl; Charles River) Dosage:14.5 mg/kg Administration:S.c.; daily; 28 days Result:Had shown a dramatic shrinkage of the tumors.Animal Model:CD1 male mice of 25-30 g Dosage:10 mg/kg (Pharmacokinetic Study) Administration:Intravenous injection Result:Had t1/2 of 1.26 hours, CL of 27.13 ML/min/kg, and Vd of 2.80 L/kg.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

GADD45β/MKK7
Research Area

——
Indication

——

CAS Number

1809784-29-9
Formula Weight

525.6
Molecular Formula

C26H35N7O5
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/ml (190.26 mM); Ethanol:100 mg/ml (190.26 mM); Water:100 mg/ml (190.26 mM)
SMILES

CC(=O)N[C@H](CC1=CC=C(C=C1)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N
Chemical Name

——

1.Tornatore L, et al. Cancer Cell. 2014, 26(4), 495-508.

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