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DSS30
CAS No. 883027-32-5
DSS30( —— )
Catalog No. M35558 CAS No. 883027-32-5
DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 532 | Get Quote |
|
| 5MG | 787 | Get Quote |
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| 10MG | 1074 | Get Quote |
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| 25MG | 1463 | Get Quote |
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| 50MG | 1822 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 500MG | 4410 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDSS30
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NoteResearch use only, not for human use.
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Brief DescriptionDSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).
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DescriptionDSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
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In VitroDSS30 (50 μM, 2 hours) inhibits the activity of the P25/CDK5 complex by up to 50% and the phosphorylation of BACE1 or Tau.Western Blot Analysis Cell Line:Expressed P25 PC12tet-off cell lines Concentration:50 μM Incubation Time:8 hours Result:Inhibited BACE1 phosphorylation by 12%.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetBeta Amyloid
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RecptorBeta Amyloid | CDK | BACE
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Research Area——
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Indication——
Chemical Information
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CAS Number883027-32-5
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Formula Weight367.87
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Molecular FormulaC16H14ClNO3S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC=1C=2C(SC1S(NC3=C(OC)C=CC=C3)(=O)=O)=CC=C(Cl)C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sul-Hee Chung, et al. Pharmaceutical composition comprising a p25/cdk5 inhibitor for preventing or treating a neurodegenerative disease. WO2006075808
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