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DSPE-PEG4-DBCO

CAS No. 2112738-14-2

DSPE-PEG4-DBCO( —— )

Catalog No. M33549 CAS No. 2112738-14-2

DSPE-PEG4-DBCO is a PEG-based linker for PROTACs that joins two essential ligands, essential for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 117 Get Quote
5MG 173 Get Quote
10MG 255 Get Quote
25MG 413 Get Quote
50MG 610 Get Quote
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Biological Information

  • Product Name
    DSPE-PEG4-DBCO
  • Note
    Research use only, not for human use.
  • Brief Description
    DSPE-PEG4-DBCO is a PEG-based linker for PROTACs that joins two essential ligands, essential for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
  • Description
    DSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PROTACs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2112738-14-2
  • Formula Weight
    1282.67
  • Molecular Formula
    C71H116N3O15P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(CCNC(CCOCCOCCOCCOCCC(NCCOP(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(=O)O)=O)=O)(=O)N1C=2C(C#CC=3C(C1)=CC=CC3)=CC=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
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