DSP-1053( DSP1053 )

Catalog No. M10599 CAS No. 1176326-78-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DSP-1053
Note

Research use only, not for human use.
Brief Description

DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.
Description

DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo.Depression Phase 1 Discontinued.
In Vitro

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In Vivo

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Synonyms

DSP1053
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Neurological Disease
Indication

Depression

CAS Number

1176326-78-5
Formula Weight

660.62
Molecular Formula

C32H38BrNO7S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

6-(2-{4-[4-Bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate

1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1;26(8):1614-1627. 2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142.

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