Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - DS-1001b

DS-1001b

CAS No. 1898207-64-1

DS-1001b( —— )

Catalog No. M21053 CAS No. 1898207-64-1

DS-1001b is an ?inhibitor of ?mutant IDH-1 (Isocitrate Dehydrogenase-1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 39 Get Quote
5MG 65 Get Quote
10MG 110 Get Quote
25MG 177 Get Quote
50MG 335 Get Quote
100MG 500 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    DS-1001b
  • Note
    Research use only, not for human use.
  • Brief Description
    DS-1001b is an ?inhibitor of ?mutant IDH-1 (Isocitrate Dehydrogenase-1).
  • Description
    DS-1001b is an ?inhibitor of ?mutant IDH-1 (Isocitrate Dehydrogenase-1).
  • In Vitro
    Cell Proliferation Assay Cell Line:JJ012, L835 Concentration:0.1, 1, 10 μM Incubation Time:14 days Result:Inhibited cell proliferation in a dose-dependent manner. GI50 values for JJ012, L835 are 81 and 77 nM.RT-PCR Cell Line:L835 Concentration:10 μM Incubation Time:6 weeks Result:Upregulated the expression of SOX9, RUNX2, COL2A1, COL10A1 and ACAN.Cell Cycle Analysis Cell Line:JJ012 Concentration:1 μM Incubation Time:7 days Result:Induced G1 phase arrest. Increased the percentage of cells in the G0/G1 phase by 5.4% and decreased that of cells in the S phase by 4.4%.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    IDH1
  • Research Area
    Cancer
  • Indication
    Glioma

Chemical Information

  • CAS Number
    1898207-64-1
  • Formula Weight
    608.92
  • Molecular Formula
    C29H29Cl3FN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:14 mg/mL (22.99 mM)
  • SMILES
    CC(C)(C)N.Cc1cn(C(=O)c2c(-c3c(Cl)cc(Cl)cc3Cl)noc2C(C)(C)F)c2cccc(/C=C/C(=O)O)c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yoshiki A Yohei M Toshihiko W et al. ACT-14 A FIRST-IN-HUMAN STUDY OF MUTANT IDH1 INHIBITOR DS-1001B IN PATIENTS WITH RECURRENT GLIOMAS[J]. Neuro Oncology Advances(Supplement_2):Supplement_2.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 4-Hydroxyderricin

    4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.

  • FX-11

    FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2).

  • IMPDH2-IN-2

    IMPDH2-IN-2 is a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH) (Ki,app: 14 μM) and a potential anti-tuberculosis agent, exhibiting moderate antibacterial effects with MIC values of 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively.

Sign In Join Free