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DPA-714

CAS No. 958233-07-3

DPA-714( —— )

Catalog No. M25016 CAS No. 958233-07-3

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DPA-714
  • Note
    Research use only, not for human use.
  • Brief Description
    DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM).
  • Description
    DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully assesses for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
  • In Vitro
    ——
  • In Vivo
    [18F]DPA-714 binding significantly increases in vivo as a result of AD‐like pathology and age in APPswe×PS1Δe9 mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TSPO
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    958233-07-3
  • Formula Weight
    398.47
  • Molecular Formula
    C22H27FN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (104.57 mM; Need ultrasonic)
  • SMILES
    CCN(CC)C(Cc1c2nc(C)cc(C)n2nc1-c(cc1)ccc1OCCF)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814-22.
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