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DM-NOFD
CAS No. 865488-53-5
DM-NOFD( Dimethyl ester NOFD | N-oxalyl-d-phenylalanine )
Catalog No. M16287 CAS No. 865488-53-5
The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDM-NOFD
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NoteResearch use only, not for human use.
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Brief DescriptionThe dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM.
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DescriptionThe dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.
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In Vitro——
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In Vivo——
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SynonymsDimethyl ester NOFD | N-oxalyl-d-phenylalanine
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF/HIF Prolyl-hydroxylase
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Research Area——
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Indication——
Chemical Information
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CAS Number865488-53-5
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Formula Weight265.265
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Molecular FormulaC13H15NO5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OC)[C@@H](CC1=CC=CC=C1)NC(C(OC)=O)=O
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Chemical NameDimethyl N-oxalyl-d-phenylalanine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73.
2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1.
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