DLK-IN-14

Research use only, not for human use.

A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM.

A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM; displays no significant inhibitory activity against a panel of 220 kinases (<70% inhibition at 1 uM); reduces JNK phosphorylation (p-JNK) in HEK293 cells with IC50 of 0.195 uM, reduces p-MKK4 and p-JNK in models of chronic neurodegeneration.

——

——

DLK inhibitor 14 | MAP3K12-IN-14

MAPK/ERK Signaling

MEK

MEK

——

——

1620574-24-4

423.44

C20H24F3N5O2

>98% (HPLC)

DMSO : 62.5 mg/mL 147.60 mM

CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C

2-Pyridinamine, 5-[1-(1-methylethyl)-5-[(1α,5α,6α)-3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluoromethoxy)-

(-20℃)

With Ice Pack

≥ 2 years