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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - DL-Homocysteine

DL-Homocysteine

CAS No. 454-29-5

DL-Homocysteine( 2-Amino-4-mercaptobutyric acid )

Catalog No. M19720 CAS No. 454-29-5

DL-Homocysteine is a potential marker for tumor cell growth. increased plasma homocysteine is a risk factor for coronary heart disease and carcinogenesis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DL-Homocysteine
  • Note
    Research use only, not for human use.
  • Brief Description
    DL-Homocysteine is a potential marker for tumor cell growth. increased plasma homocysteine is a risk factor for coronary heart disease and carcinogenesis.
  • Description
    DL-Homocysteine is a potential marker for tumor cell growth. increased plasma homocysteine is a risk factor for coronary heart disease and carcinogenesis.
  • In Vitro
    DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM.
  • In Vivo
    DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus.
  • Synonyms
    2-Amino-4-mercaptobutyric acid
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    454-29-5
  • Formula Weight
    135.19
  • Molecular Formula
    C4H9NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM;Water:Soluble
  • SMILES
    NC(CCS)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.DL-Homocysteine et al. Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist kynurenic acid. J Neurosci Res. 2005 Feb 1;79(3):375-82.
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